此外，实际工业分离过程远比模拟体系复杂，例如在使用共结晶技术进行分离API 时，CF 的加入有时会引起溶液性质的改变，从而影响到API在溶剂体系中的溶解能力。因此，深入研究热力学行为是未来的主要研究方向之一。

总之，共结晶技术在有机小分子中的应用是一个新颖的研究方向。虽然还存在没有系统的CF 选择标准，热力学行为研究不足等问题，但是并不影响共结晶代替传统的成盐成为有机小分子分子纯化的新选择。CF 选择标准的建立、热力学行为等方面将是研究的重点。

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